Case 4: AML with t(8;21)
A single, thin, tapered Auer rod is classic for AML with t(8;21)
Other key points:
There is an association with systemic mastocytosis in approximately 10% of cases
RUNX1::RUNX1T1 is associated with the 8;21 translocation
This fusion protein blocks transcription of genes involved in hematopoietic differentiation
The prognosis of AML with t(8;21) RUNX1::RUNX1T1 is favorable. Although, the presence of additional mutations (such as KIT) can be associated with poorer prognosis
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— Clarissa E. Jordan, MD (@pathcejmd) February 10, 2022
Trying something different-rapid fire review for trainees
Blasts w this *single* (hint) finding are classically seen in which AML subtype? (Poll⬇️)#PathTwitter #MolecularPath #MedEd @MayoClinicPath
(P.S. Always learning - I welcome any feedback!) pic.twitter.com/KiuAEEHEtm